Along the way I've had rabbits that came from all sorts of backgrounds.
Timothy, my current bun, came from a breeder. I have 3 more on the way, all from breeders. Tim has always been healthy and I'd go back to his breeder any time. I've had good luck from breeders generally. I dealt with one breeder who had Hollands and AFLs. I took 2 AFLs from her, sort of as a favor, they both were a mess. They had to be shaved, which was an experience in itself, and they were thin under all their mats. One went into stasis from the stress of everything, he was the worst off to start with. He had seizures and by the time it was all over, he had lost his sight. But when it was all over, he was an amazing boy who was so friendly and wonderful.
(The doe was pregnant, but she somehow managed to have 6 beautiful, healthy girls who all went to wonderful homes. I still get photos of them.)
My first rabbit came from a reptile show. She was being sold as snake food. Daisy made me love rabbits and everything that goes along with them. I had 2 others from reptile shows. Daisy and Orion were healthy, Elvis (a Californian) had ear issues because the idiot who bred them picked all his rabbits up by their ears. The cartilage in his ears had been so badly damaged, they basically flopped and he was prone to ear infections. But I'd do it again just because to rescue them was such a great thing. It was so worth it.
I've had a couple of buns from pet stores. But I've not really had any problems with them, although, I've seen the horrors and heard enough stories. They weren't well socialized and that was a challenge...
I've gotten them from friends and from the Humane Society and a rabbit rescue. On the whole, they were pretty good.
I've actually been really lucky. I haven't had too many health issues, some, but not too many. And while some just weren't social, I recognize that like people and other animals, some just aren't as human dependent. I'm always leery of the pet store, but I also know that it's fairly impossible for a pet store to give their rabbits everything they need and honestly, as far as exercise and socialization, I've seen some breeders that are much worse then any pet store. So basically I just think it's hit or miss. So, on the whole, I'm not opposed to getting rabbits from anywhere.