I can barely pick up Nibbles without him kicking up a storm, so picking him up AND trimming his nails? Um, no.
I really struggle to pick up Junie at all. So nails for her are a no-go, too.
It's way easier to take them to the vet a couple miles away from us. They don't like the car ride, but it's probably less stressful for them in the end if a vet does it instead of struggling against me for who knows how long!