Chronic rhintis due to Pseudomonas Aeruginosa

[Georgia4949]

Hello! I learnt for you from House Rabbit Society. Please, i want your advice about my rabbit' s problem. My rabbit is having chronic rhinitis that caused by Pseudomonas Aeruginosa, which has become resistant to almost all antibiotics. There is no other treatment that we can try. Our doctor has found some research indicate that green tea extract neutralizes resistant to many antibiotics Pseudomonas, so we are thinking to try this last solution. Our doctor thought to do it with nebulizer and we were thinking that it was a good idea but an other doctor said that it may be a risk because if my rabbit inhales green tea, this may cause an allergic reaction in the lungs. So the other doctor suggested that we should try it with throwing some drops into the nasal cavities, but we aren't sure if the drop can reach deep into the nasal cavities. So i am looking for someone that knows something about similar issues or have tried something similar in order to advise us. We are in Greece, but i have heard good things about you and your knowledge, so i decided to send you an e-mail. Any other opinion about how to treat Pseudomonas would be very useful!I' m looking foward to your anser and your opinion. Thanks from now!

Georgia!

 

[Watermelons]

What type of antibiotics have been used?
Was a culture done?
Injectable antibiotics?
Has any other substance been attempted via nebulization?
What type of green tea are you talking about here? There is whats called Matcha which is whole leaf vs tea leaves in a tea bag....

 

[squidpop]

Ask your vet if he can try Zithromax/Azithromycin. I used this drug on my rabbits and they got better. It says in this article it was effective on Pseudomonas Aeruginosa. With my rabbits they where given pfiezer brand Zithromax Zithromax/Azithromycin for human children, had to get it from my pharmacy.


http://www.ncbi.nlm.nih.gov/pubmed/15793115

Azithromycin exhibits bactericidal effects on Pseudomonas aeruginosa through interaction with the outer membrane.
Imamura Y1, Higashiyama Y, Tomono K, Izumikawa K, Yanagihara K, Ohno H, Miyazaki Y, Hirakata Y, Mizuta Y, Kadota J, Iglewski BH, Kohno S.
Author information
Abstract
The aim of the present study was to elucidate the effect of the macrolide antibiotic azithromycin on Pseudomonas aeruginosa. We studied the susceptibility to azithromycin in P. aeruginosa PAO1 using a killing assay. PAO1 cells at the exponential growth phase were resistant to azithromycin. In contrast, PAO1 cells at the stationary growth phase were sensitive to azithromycin. The divalent cations Mg2+ and Ca2+ inhibited this activity, suggesting that the action of azithromycin is mediated by interaction with the outer membranes of the cells, since the divalent cations exist between adjacent lipopolysaccharides (LPSs) and stabilize the outer membrane. The divalent cation chelator EDTA behaved in a manner resembling that of azithromycin; EDTA killed more PAO1 in the stationary growth phase than in the exponential growth phase. A 1-N-phenylnaphthylamine assay showed that azithromycin interacted with the outer membrane of P. aeruginosa PAO1 and increased its permeability while Mg2+ and Ca2+ antagonized this action. Our results indicate that azithromycin directly interacts with the outer membrane of P. aeruginosa PAO1 by displacement of divalent cations from their binding sites on LPS. This action explains, at least in part, the effectiveness of sub-MICs of macrolide antibiotics in pseudomonal chronic airway infection.

 

[Georgia4949]

We have already tried zithromax, baytril, injectable amikacin, doxycicline, ciproxin and injectable and also nebulizing with marbofloxacin. But there is no result.. We have also done many x-rays and rhinoscopy but we haven't found anything.

 

[Georgia4949]

Moreover, we did many times culture and sensiτιvity test and we tried all the possible antibiotics..

 

[JBun]

Is your vet certain your rabbit has an upper respiratory infection and that pseudomonas is the primary cause? Culture swabs can sometimes be inaccurate, especially if the sample isn't taken deep within the nasal cavity. Did your vet do a deep nasal swab? What symptoms does your rabbit have indicting a respiratory infection? Has there been any white or colored discharge, as opposed to clear?

Other antibiotics that may be effective: cephalosporins(eg. convenia) and gentamycin.
http://wildpro.twycrosszoo.org/S/00dis/Bacterial/Pseudomonas_Infection.htm
http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa

I think the problem with using green tea is that for anything nebulized and that is going to be inhaled, you want to ensure it is sterile. I don't know if you can get this in Greece, but something used in the UK for nebulizing rabbits with respiratory infections, is a disinfectant called F10, mixed with sterile water.

Something else that may be helpful is for your vet to consult with a rabbit specialist. I don't know if there are any in Greece, but there are several in the UK.

Frances Harcourt Brown https://www.harcourt-brown.co.uk/
Mark Rowland http://trinityvetcentre.com/Trinity_Vet_Centre/Home.html
Molly Varga http://www.cheshirepet.co.uk/
Richard Saunders http://www.highcroftvet.co.uk/
Iain Cope http://www.cambridgevetgroup.co.uk/vets/

 

[squidpop]

Gosh I can't believer there where that many antibiotics used and nothing worked Since you've already tried so many antibiotics I do think trying to contact one of the specialists Jbun mentioned to see if any of them have had any luck with treating Pseudomonas Aeruginosa and what drugs the used, who knows maybe they found something that works.

 

[Georgia4949]

Yew, we did a very deep culture when we did the rhinscopy. From then we did another two times culture and sensitivity test and all showed Pseudomonas. I am very disappointed :sad: The symptoms are sneezing and thick white discharge.

 

[JBun]

I think you may just need to continue trying different antibiotics til you find one that works. I read of one vet using septrin for a rabbit with this type of respiratory infection, but I don't know if this antibiotic worked or not.

If you can get a hold of the F10 disinfectant, nebulizing with that with a heavy dilution of sterile water, may help as well. Your vet would need to look up the correct ratio.

One thing that other rabbit owners have found to help boost a rabbits immune system, that may in turn help your rabbit fight off the infection better, is supplementing your rabbit with coneflower/echinacea each day. Some people feed some of the cut dried herb, others use a non alcoholic tincture.

Also some other things vets will prescribe rabbits with a respiratory infection, is meloxicam/metacam to help reduce inflammation in the airways, and bisolvon to help thin the mucous and make it easier for the rabbit to expel. So it may be worth asking your vet about these medications as well, if you aren't already using them.

 

[BlazeBunnies]

If your rabbit isn't showing signs of improvement. He/she should be pts, he/she would be suffering and it's not really fair. It's good to know that you are dedicated to your pets and that you have tried so many things hope it all goes well

 

[Georgia4949]

One doctor from Canada told me aboyt f10 antiseptic solution and we have already ordered it. We are going to do nebulizing with this product for several weeks. Do you think it will work?

 

[Georgia4949]

I love my bunnies as like they are my children and i will do everything for them. :sickbunny:

 

[Evija]

Hello, found your answer in the forum as I was trying to find anything regarding houserabbits and Pseudomonas Aeruginosa.
7 month ago we found rabbit abandoned on the street in very bad condition. After a long medical treatment our wet found the same bacteria....
We have similar story - nothing helps.
Georgia, if you still use this site, could you please tell how things went for your rabbit?
We were also inhaling F10. It seemed to help just a little bit as xray became better, but still half full of Pseudomonas Aeruginosa. Yesterday our wet made kind of operation, she made 2 small holes in rabbys nose bone and tried to clean. She said she managed to clean some staff out of the nasal cavities. Now our rabbit is still at vet. She is having bad times after deep anesthesia. We dont know if she will manage to recover and if surgery made any progress..
Please please comment your case

 

[maiyaeh]

my little bun sneezed a lot and had running nose in August 2017. His blood test result confirmed that he has chronic infection with elevated WBC. The vets gave him enrofloxacin and other antibiotics but both didn't work well. He was very thin at that time. So I gave him more pellets, sherwood's immune support supplement and enchinacea purpurea extract. His symptoms went away within 10 days
If you can find enchinacea purpurea in Greek, you could try giving this herbal supplement to your bun. It boots immune system in low dose and acts as a natural antibiotic in high dose