I have a doe that has excessive inbreeding in her background, including a brother to sister mating, so it can be done. However, I advise against it if you're a new time breeder.
I personally don't like imbred stock, and am trying to outbreed - so much that's been doing, seeing as how every REW Mini in my barn is related somehow except for one. Everytime I buy new stock, I end up finding out later on that they're related! hah. So this means I'm going to have to get stock from out of state, or introduce Chinchilla (which my REWs mask) in order to get in new lines.
Emily