Hi,
I suspect what caused this is something like enteritis. It happens quite often in cottontails raised in captivity but will also strike domestics since their guts are the same. With cottontails, it occurs somewhere around 21 days old. It usually strikes without much warning....when we have seen this in both cottontails and domestics....they usually start to wobble and then fall over and death occurs pretty rapidly. If you will notice the timing, it happens about weaning. As a rabbit weans, there is a rapid change in the pH in the GI tract. The bacteria there is still not firmly established and is extremely delicate. The violent change in climate in the GI is too much for the bacteria to take and it starts to die off. The decaying bacteria and the harmful bacteria that grows, most often clostridium, bascially poisons the rabbit. Once this happens, it is impossible to reverse and death usually comes quickly. I have had some success with manually controlling the GI conversion using lactobacillus acidophilus. While it is common thought that it's the bacteria in this compound that is working...it's actually not. It is acidifying the gut...look at the first few letters. Many of the books will tell you never to acidify a rabbit's gut and then turn around and suggest using acidophilus. The idea I have been using is to start the conversion of the gut about 10 days old and increase the acidity as we approach weaning (remember that cottontails wean earlier than domestics). I have had particular success in using lactobacillus casei strains. More work to be done. And this happens sometimes when everything has been done correctly. I have also been treating some test groups of cottontails by "shotgunning" an antibiotic. This particular antibiotic is quite good at targeting the harmful bacteria that grows during these events. More work on that next rescue season. This is the very reason that few people are willing to raise cottontails in rehab. You do all the right things, the right formula, the feedings every couple of hours...and with me, feeding tubes...only to lose them at wean. And it does happen in domestics and sounds to me like that is what happened here.
Randy