Honestly I dont think they care. I wondered the same thing when Oreo had her babies. I was scared that it would send her into a depression (dogs get sad and I thought rabbits the same). When my friend took all 3 babies I think Oreo was super happy. She layed on the floor level a lot, what she couldnt do when the babies were there because they would nurse! I didnt notice a change in appetite or attitude. She didnt really care. We had a play date yesterday and I dont think we can do that again. Oreo tried biting and lunged at all the babies. Maybe she thought they were coming back?! LOL! Good luck!