with confidence! Seriously. Pet bunnies tend to weigh in the 2-8 lb range. Pick up your bunny, put it's feet on something as quickly as possible, and if you need to cover it's head to calm it down. Applying pressure can help calm the bunny.
But be confident and DO NOT let the bunny get away from you. Otherwise it just teaches the bunny you aren't safe AND that by struggling he can get away.
DO NOT pick up by the ears or scruff them. Both are hard on the bunny.
Pick bunny up by scooping him under his belly and drawing him into you.
Some people feel more confident teaching bunny to hop on a towel and then using the towel to pick bunny up. Others use a basket to carry it around.