I have a spayed 6-year-old Dutch rabbit, Penelope. I took her to the vet 4 months ago for a routine checkup, and they did blood work and said that her kidney levels were on the high end of normal. She seemed fine until this past Sunday when she stopped eating. I took her to another vet and they did blood work. Creatinine: Was 1.3, now 3.3 (I think the normal is max 2.3) BUN: was 18, now 100 (normal is 13-30) So it got way worse. The vet is telling me it is probably genetic and I didn't do anything wrong, but I am worried because my 8-year-old Mini rex just died about 4 months ago from kidney disease/massive amounts of bladder sludge. I know they are technically seniors, but I've never had this issue with my rabbits. This is very depressing, because I know kidney failure is not reversible, and considering how it got so much worse so fast I'm afraid she doesn't have long to go. I feed Oxbow timothy hay, about 1/8-1/4 cup of Oxbow adult Essentials per day, and romaine lettuce. I give filtered water. I just don't think I can improve this diet much. Out of paranoia, I got rid of the old bag of rabbit pellets and bought Oxbow Garden since that's what Petco had (seems to have good ingredients). I also stopped Romaine and started giving red leaf lettuce, dandelion, and cilantro. I'm worried it might be E coli from the Romaine, but wouldn't that cause diarrhea? I think I should bring a fecal sample in to check for this. She is eating now. on Sunday I started feeding Critical Care from a syringe. The only thing she would eat is a bag of dried plantain weed I got from a UK rabbit company (, which had me worried because I can't buy that here. Monday I took her to the vet and got blood work, sub Q fluids, an antibiotic, and Bene-Bac. I fed about 4 TBSP of Critical Care. Tuesday she started eating lots of dandelion and some hay. I fed about 2 TBSP of Critical Care, and I also started mixing unflavored Pedialyte into her water. Yesterday she continued to eat lots of greens and actually ate some pellets, which she hadn't touched since Sunday. I'm having a hard time telling how much hay she's eating, since I put a lot of Timothy and orchard grass hay in for her. I fed 1 TBSP of Critical Care just to make sure she was getting enough food.